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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46ff45a458d0ea68784f421d2a260e2ec382397e42f3d0cdf61a64e1753ef53b' 
  AND token = 'XkWy/JRpGNun/giRl77FER4Lki8O1IDWMj9uh9Ub8Fc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}